Discover a selection of 15 homes, 374 apartments, and other vacation rentals in Santo Spirito that are perfect for your trip. Whether you’re traveling with friends, family, or even pets, vacation homes have the amenities you need and want for your stay, which might include a garden and WiFi. No matter what you're looking for, you'll find a rental to meet everyone's needs, including a place that's non-smoking or offers accessibility.